Jenner

The Jenner Institute

Vaccination at the Jenner Institute

The world needs more and better vaccines to control many debilitating and devastating diseases of man and his domesticated animals. Vaccines offer the only practical solution to preventing the damaging effects of many viral, bacterial and parasitic infections, but progress towards the development of new products is often slow and can be hindered by the lack of an effective interface between the interests of scientists working on either human or animal diseases; some of which such as tuberculosis and influenza may affect both man and animals.

The new Jenner Institute is now in place to bridge the gap between human and veterinary research in the context of deriving new, better or completely novel vaccines for diseases that have a massive impact across the globe. Although in its early days, the Jenner Vaccine Foundation is already having an impact and improving the prospects for the better control of old diseases. If this progress is to continue and contribute to enabling the world to meet the United Nations Millennium Development goals by 2015 more, and more certain, financial support is needed.

Vaccination has already made major contributions to human and animal health, some examples of which are given

Vaccination has the potential to do even more. The development of human and animal vaccines has, in the past, followed rather separate tracks. By bringing together distinguished scientists to work on complementary approaches to develop human or animal vaccines and by sharing expertise and resources, the Jenner Vaccine Foundation (JVF) seeks to accelerate the development of effective vaccines that will help to sustain the health of man and his livestock in the 21st century, especially in the developing world.

HUMAN VACCINES		ANIMAL VACCINES
Smallpox	Through the success of the global eradication campaign (WHO offensive in 1967), smallpox was eradicated from the planet in 1977.	Foot-and-mouth disease	Current foot-and-mouth disease vaccines, although yielding short-lived protection, are widely deployed throughout the world where FMD virus is endemic.
Polio	Since 1988, the worldwide use of poliovirus vaccines has reduced the number of annual diagnosed cases by >99%.	Rinderpest	Use of a vaccine against rinderpest (cattle plague) virus combined with first class diagnostics will result in the formal eradication of rinderpest from the planet in 2010.
Measles	The first single dose vaccine was introduced in 1963 and the current two dose regime now protects 99% of those vaccinated.	Coccidiosis	Vaccination is now an important strategy for control of avian coccidiosis.
HPV	Two HPV vaccines are available to prevent infection with HPV types 16 and 18 that cause 70% of cervical cancer.	Marek's disease	A vaccine was first introduced in 1970 for the prevention of MD in poultry. Vaccination is the only method to prevent the development of tumours when poultry are infected by the virus.
Haemophilus influenzae type b (Hib)	In 2000, Hib was estimated to have caused two to three million cases of serious disease, notably pneumonia and meningitis, and 386 000 deaths in young children. Now it is used in the routine immunisation schedule of more than 100 countries and WHO recommends the use of Hib conjugate vaccines in all countries.	Canine distemper vaccine	Vaccines have been available since the 1950s. Pups are typically immunised with canine distemper modified live virus. A recombinant canarypox vectored-vaccine expressing distemper virus proteins is available. Prior to widespread vaccination, distemper was a major killer of dogs but today is rarely encountered.